Telmisartan, Amlodipine And Hydrochlorothiazide

Angiotensin-II Antagonist · Angiotensin II antagonist/Calcium antagonist/Thiazide diuretic

Indications

Treatment of essential hypertension.

Dosage

Adults: 1 tab once daily. Children: Not recommended.

Adverse Effects

Fatigue, influenza like symptoms, dizziness, nausea, diarrhoea, sinusitis, upper RTI, abdominal pain, somnolence.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Hepatic impairment. Severe renal impairment. Precautions: Elderly.

Interactions

Avoid co-adm with aliskiren in patients with diabetes and renal impairment. Lithium. Digoxin. NSAIDs. Antidiabetics. Cholestyramine and Colestipol resins. Sildenafil. Simvastatin. Immunosuppressants.

Pharmacokinetics

TELMISARTAN: Onset of action: 1-2 hrs. Duration: Up to 24 hrs. Metabolism: Hepatic. Bioavailability (dose dependent): 42%-58%. Hepatic impairment: Reaches 100%. Half-life elimination: Terminal: 24 hrs. Time to peak, plasma: 0.5-1 hr. Excretion: Faeces (97%). AMLODIPINE: Onset of action: Antihypertensive effect: Significant reductions in blood pressure at 24-48 hrs after first dose. Duration: Antihypertensive effect: At least 24 hrs. Discontinuation after 6-7 wks of treatment: Duration extends to at least 72 hrs. Absorption: Well absorbed. Metabolism: Hepatic. Bioavailability: 64%-90%. Half-life elimination: Terminal (biphasic): 30-50 hrs. Time to peak, plasma: 6-12 hrs. Excretion: Urine. HYDROCHLOROTHIAZIDE: Onset of action: Diuresis: Infants: 2-6 hrs. Adults: Approx. 2 hrs. Peak effect: 4-6 hrs. Duration: Infants: 8 hrs. Adults: 6-12 hrs. Absorption: Well absorbed, absorption is…

Compiled by Healify Pharmacy from published drug references. How we compile it →

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