Sumatriptan and Naproxen

Antimigraine Preparations · 5HT1-agonist/Propionic acid

Indications

Acute treatment of migraine with or without aura.

Dosage

ORAL: Adults: 1 tab of 85/500 mg. After 2 hrs, administer 2nd dose if response with first dose was not satisfactory. Max: 170/1000 mg/day. Children =12 yrs: 1 tab of 10/60 mg daily. Max: 85/500 mg daily. =12 yrs: Not recommended.

Adverse Effects

Dizziness, somnolence, nausea, chest discomfort/chest pain, neck/throat/jaw pain/tightness/pressure, paresthesia, dyspepsia, dry mouth, hot flush and muscle tightness.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe renal and hepatic impairment. Patients who are going to have CABG surgery. Uncontrolled hypertension. Blood circulation problems. History of asthma or heart disease. Wolff-Parkinson-White syndrome. Precautions: Mild to moderate renal and hepatic impairment. Elderly. Patients with history of peptic ulcer or GI bleeding.

Interactions

Lithium, methotrexate, heparin, warfarin, diuretics, steroids (such as prednisone), antidepressants (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, trazodone, vilazodone).

Advice to Patient

Take tab with or without meals. Do not break, chew or crush tab, swallow whole. Do not take aspirin or aspirin containing medications during treatment. Do not take within 24 hours before or after using another migraine headache medication. Avoid alcohol during treatment. Be cautious while driving or doing tasks that require alertness. Inform prescriber before taking any OTC medication for pain or allergy. Contact prescriber if there is chest pain, shortness of breath, irregular heartbeat, significant rise in blood pressure, weakness and slurring of speech, unexplained weight gain or oedema, signs or symptoms of hepatotoxicity, or gastrointestinal toxicity, skin rash or any other sign of hypersensitivity.

Pharmacokinetics

SUMATRIPTAN: Onset of action: Oral: Approx. 30 min. Intranasal: Soln: Approx. 15-30 mins. SC: Approx. 10 mins. Peak effect: ORAL: 2-4 hrs. Metabolism: Hepatic; extensive first-pass metabolism following oral administration. Bioavailability: Intranasal: Soln: 17%. Powd: 19% (compared to SC). Oral: 15%. SC: 97% ± 16%. Half-life elimination: Distribution: 15 mins. Terminal: 2 hrs. Time to peak, serum: Oral: 2-2.5 hrs. Intranasal: Powd: Approx. 45 mins. SC: 12 mins. Excretion: Intranasal: Urine. Oral: Urine. Faeces. SC: Urine. NAPROXEN: Onset of action: Analgesic: 30-60 mins. Duration: Analgesic: <12 hrs. Absorption: Oral: Almost 100%. Metabolism: Hepatic. Bioavailability: 95%. Half-life elimination: Children: 8-17 hrs. Children 8-14 yrs: 8-10 hrs. Adults: Normal renal function: 12-17 hrs. Moderate to severe renal impairment: Approx. 15-21 hrs. Time to peak, serum: Tab, naproxen: 2-4 hrs.…

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.