Strontium Ranelate

Drugs affecting Bone Metabolism · Antiosteoporotic agent

Indications

Post-menopausal osteoporosis.

Dosage

Adults: 1 sachet daily in water, preferably at bedtime. Avoid food for 2 hr before and after taking granules, particularly calcium containing products, avoid concomitant antacids containing aluminium and magnesium hydroxide for 2 hr after taking granules. Children: Not recommended.

Adverse Effects

Nausea, diarrhoea, venous thromboembolism, headache, dermatitis, eczema, very rarely vomiting, abdominal pain, stomatitis and hypersensitivity reactions, including rash, pruritus, urticaria and angioedema. Severe allergic reaction have been reported.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Precautions: Predisposition to thromboembolism; interferes with colorimetric measurements of calcium in blood and urine.

Interactions

Antibacterials.

Advice to Patient

Take oral form atleast 2 hours after meals, milk, milk products or calcium supplements. Dissolve only in plain water and immediately drink it. Preferably, it is taken at bedtime.

Pharmacokinetics

Absorption: Slow. Metabolism: Not metabolized. Bioavailability: Absolute: 25%. Calcium or food decreases the bioavailability by about 60-70%. Half-life elimination: 60 hrs. Time to peak, plasma: 3-5 hrs. Excretion: Via renal and GI tract.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.