Sotagliflozin

Hypoglycaemic excluding Insulin · SGLT1 and SGLT2 inhibitors

Indications

Indicated to reduce cardiovascular death, heart failure hospitalizations, and urgent heart failure visits in adults with heart failure or chronic kidney disease.

Dosage

Adults: Initially 200 mg orally once daily. Can be up-titrated to 400 mg once daily after =2 wks, as tolerated. In patients with decompensated heart failure, begin dosing when patients are haemodynamically stable. Withhold Sotagliflozin at least 3 days, if possible, prior to major surgery or procedures associated with prolonged fasting. Children: Not recommended.

Adverse Effects

Urinary tract infections, volume depletion, diarrhoea, hypoglycaemia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Patients on dialysis or GFR <25 mL/min/1.73m2. Moderate or severe hepatic impairment. Precautions: Renal impairment; assess renal function before starting treatment. Hypotension; correct volume status before starting treatment. Diabetic ketoacidosis. Elderly.

Interactions

Digoxin, diuretics (e.g. furosemide, hydrochlorothiazide), insulin, insulin secretagogues (e.g. sulfonylureas such as glipizide or glyburide, lithium, UGT inducers (e.g. rifampin, carbamazepine, phenytoin, phenobarbital).

Advice to Patient

Take tab once daily up to 1 hr before your first meal of the day. Swallowwhole tab. Do not crush, chew, split or break it. If you miss a dose by more than 6 hrs, skip it and resume the next day. Drink plenty of water throughout the day to avoid dehydration. Riseslowly from sitting or lying down to avoid dizziness. Discontinue medication and report immediately if you develop severe vomiting, diarrhoea and unable to eat/drink. Seek emergency care for severe nausea, vomiting, or stomach pain, which are signs of ketoacidosis. Maintain excellent personal hygiene to prevent yeast infections caused by sugar in the urine. Report immediately if you feel burning during urination, pelvic pain, or a sudden fever. Seek emergency help for rare but severe pain, redness, or swelling in the genital area. Stop taking this medication at least 3 days before any scheduled surgery or fasting.

Pharmacokinetics

Bioavailability: Absolute: Approx. 25%. Metabolism: Hepatic. Half-life elimination: Unchanged form: 21-35 hrs. M19 metabolite: 19-26 hrs. Time to peak, plasma: 1.25-3 hrs (after a single dose). 2.5-4 hrs (after multiple doses). Excretion: Urine (57%). Faeces (37%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.