Somatropin

Growth Hormones · Growth hormone

Indications

Growth failure in children due to deficiency of endogenous growth hormone. Turner syndrome. Verified growth retardation in prepubertal children with chronic renal insufficiency. Prader-Willi syndrome in children. Replacement therapy in adults with demonstrated growth hormone deficiency.

Dosage

Children: Growth hormone deficiency: 0.025-0.035 mg/kg body weight daily by SC or IM inj. Turner syndrome: 0.045-0.50 mg/kg body weight daily by SC Injection in evening. Renal insufficiency: 0.045-0.050 mg/kg body weight daily by SC Inj. Prader-Willi syndrome:0.035 mg/kg daily or 1 mg/m² daily by SC Injection, max 2.7 mg daily. Adults: Initially 0.15-0.3 mg daily by SC Inj. Increase gradually according to individual requirements; max 1 mg daily.

Administration

Do not shake. Administer SC or IM. Rotate administration site to avoid tissue atrophy. When administering to newborns do not reconstitute with a diluent that contains benzyl alcohol. SWFI may be used as an alternative. Stability: Store at 2°C-8°C (36°F-46°F). Do not freeze. Protect from light.

Adverse Effects

Hypothyroidism, transient oedema, headache, glucosuria, hyperglycaemia, muscle pain, weakness, pain at injection site.

Risk Factor (Pregnancy/Lactation)

Contraindications: Epiphyseal fusion, tumour, acute critical illness after open heart or abdominal surgery, multiple accidental trauma or acute respiratory failure. Precautions: Intracranial lesion, diabetes, ACTH deficiency. Monitor thyroid function. Pregnancy, lactation.

Interactions

Drugs metabolised by CYP3A4.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.