Sofosbuvir

Antiviral, Systemic · Nucleotide analogue

Indications

With ribavirin (with or without peginterferon alfa) for the treatment of chronic hepatitis C.

Dosage

Adults: 400 mg once daily with food. Continue for up to 24 wk. Children: <18 yr: Not recommended.

Adverse Effects

Blood dyscrasias, anorexia, weight loss, insomnia, depression, anxiety, agitation, headache, dizziness, migraine, attention disturbances, memory impairment, blurred vision, dyspnoea, cough, GI upset, dry mouth, raised bilirubin, rash, pruritus, alopecia, dry skin, arthralgia, myalgia, muscle spasm, pain, fatigue, irritability, chills, pyrexia, flu-like illness, nasopharyngitis, asthaenia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Severe renal impairment (CrCl <30 mL/min). Precautions: Decompensated cirrhosis, patients awaiting liver transplantation. Co-infection with HBV. Severe renal impairment.

Interactions

Telaprevir, boceprevir, other direct-acting HCV antivirals. Modafinil, potent P-gp inducers (e.g. rifamycins, carbamazepine, phenytoin, phenobarbital), amiodarone, vit K antagonists.

Advice to Patient

Take with or without meals.

Pharmacokinetics

Note: The pharmacokinetic profile in paediatric patients =12 yrs of age is similar to adult patients. Metabolism: Hepatic. Half-life elimination: 0.4 hrs. Time to peak: Approx. 0.5-2 hrs. Excretion: Urine (80%). Faeces (14%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.