Sodium Stibogluconate

Scabicide & Pediculocide · Leishmaniacide

Indications

Leishmaniasis.

Dosage

Leishmaniasis: Adults: By IM or IV inj: 20 mg/kg daily for 28 days and for 20 days in cutaneous infection. Children: Not recommended.

Adverse Effects

Anorexia, nausea, vomiting, abdominal pain, diarrhoea, ECG changes, cough, headache, lethargy, arthralgia, myalgia, vertigo, fever, sweating, rash, pancreatitis, anaphylaxis, GI upset, malaise.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Significant renal impairment. Precautions: Administer IV very slowly to reduce risk of local thrombosis and stopped if coughing, vomiting or substernal pain, mucocutaneous disease; monitor ECG; heart disease; treat intercurrent infection (e.g. pneumonia). Pharyngeal or tracheal lesions. Risk factors for QT prolongation. Hepatic impairment.

Interactions

Amphotericin B deoxycholate. Drugs that prolong QT interval.

Pharmacokinetics

Absorption: IM: Well absorbed. Half-life elimination: Approx. 10 hours. Excretion: Urine (80% as unchanged drug [over 6 hours]).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.