Rosuvastatin and Valsartan

Hypolipidaemic/Anti-atheroma · Angiotensin II antagonist/HMG-CoA reductase inhibitor

Indications

Hypertension with high risk of cardiovascular event or with one of the following coincident conditions: Primary hypercholesterolaemia (type IIA including heterozygous familial hypercholesterolaemia) or mixed dyslipidaemia (type IIB)-homozygous familial hypercholesterolaemia.

Dosage

Adults: One tab once a day. Children: Not recommended.

Adverse Effects

Headache, muscle pain, dizziness.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe hepatic impairment. Severe renal impairment Precautions: History of liver disease. Hypothyroidism. Elderly. History of angioedema.

Advice to Patient

Take with or without meals. Do not take potassium salts or substitutes without consulting prescriber.

Pharmacokinetics

ROSUVASTATIN: Onset of action: Within 1 wk, maximal at 4 wks. Metabolism: Hepatic (10%). Bioavailability: 20% (high first-pass extraction by liver). Half-life elimination: 19 hrs. Time to peak, plasma: 3-5 hrs. Excretion: Faeces (90%). VALSARTAN: Onset of action: Approx. 2 hrs. Duration: 24 hrs. Metabolism: To inactive metabolite. Bioavailability: Tab: 25%. Susp: Approx. 40%. Half-life elimination: Children 1-5 yrs: Approx. 4 hrs. 6-16 yrs: Approx. 5 hrs. Adults: Approx. 6 hrs. Time to peak, serum: Children 1-16 yrs: Oral susp: 2 hrs. Adults: 2-4 hrs. Excretion: Faeces (83%). Urine (13%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.