Rho (D) Immune Globulin

Sera and Gamma Globulin · Immunoglobulin

Indications

Prevention of Rho (D) haemolytic disease of the newborn, by its administration to the Rho (D) +ve, Du -ve mother within 72 hours after the birth of her first Rho (D) +ve or Du +ve child, or after an abortion. Women who have not become sensitized to Rho (D) by previous Rho (D) +ve births.

Dosage

Adults: Inject 1 vial IM into postpartum mother within 72 hr of full term delivery of an Rho (D) positive infant. Incidence can be further reduced by giving two doses, one at 28 wk gestation, one following delivery.

Adverse Effects

Nausea, diarrhoea, chills, fever, headache, dizziness, arthralgia, myalgia, muscle spasms, low back pain, allergic reactions, injection site reactions, anaphylactic reactions, thromboembolic events. Hypotension, aseptic meningitis, acute renal failure. Rarely sometimes fatal cases of intravascular haemolysis.

Risk Factor (Pregnancy/Lactation)

Contraindications: In the treatment of idiopathic thrombocytopenia purpura not to be used in rhesus negative or splenectomized patients. Precautions: Never administer intravenously, never administer to neonate, to Rho (D) +ve or Du +ve mother, Rho (D) -ve mother previously actively immunized to Rho (D) blood factor or who has received a Rho (D) +ve transfusion. Should be given with caution with a history of prior systemic allergic reactions following the administration of human immunoglobulin preparations. Physician must weigh the benefits of immunization against the potential risks of hypersensitivity reaction to persons with isolated immunoglobulin A (IgA) deficiency. History of typical reactions to blood or blood products. Risk factors for thrombotic events or acute renal failure. Monitor for adverse reactions and anaphylactoid reactions during infusion.

Interactions

May interfere with the live vaccines to induce an immune response and a suitable interval should separate their administration.

Compiled by Healify Pharmacy from published drug references. How we compile it →

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