Pralidoxime Methylsulphate

Antidote · Cholinesterase reactivator

Indications

Treatment of poisoning due to organophosphate pesticides or related compound. Adjunct to atropine in the treatment of poisoning due to pesticides & chemicals of the organophosphate class. Treatment of overdosage by anticholinesterase drugs used in the treatment of Myasthaenia gravis.

Dosage

Organophosphate poisoning: Adults: 1-2 gm IM/IV, max dose: 12 gm/24 hr + atropine 2 mg SC/IM repeated at intervals of 5-60 min. Children: 20-60 mg/kg. Anticholinesterase overdosage 1-2 gm IV followed by increments of 250 mg every 5 min.

Adverse Effects

Drowsiness, dizziness, vision disturbances, nausea, tachycardia, headache, hyperventilation, muscular weakness.

Risk Factor (Pregnancy/Lactation)

Precautions: Renal insufficiency. Pregnancy & lactation.

Interactions

Morphine, theophylline, aminophylline, succinylcholine, reserpine and phenothiazine type tranquillisers.

Pharmacokinetics

Metabolism: Hepatic. Half-life elimination: 74-77 mins. Time to peak, plasma: 34 mins. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.