Potassium Chloride and Bumetanide

Diuretic · Loop diuretic/Potassium salt

Indications

Oedema associated with congestive heart failure, hepatic ascites and renal disease where potassium supplement is required.

Dosage

Adults: 1-4 tab daily. Children: Not recommended.

Adverse Effects

Potassium chloride: Rash, cramps, GI discomfort, thrombocytopenia, gynaecomastia. Discontinue if any symptoms of ulceration or obstruction of small bowel occur. Bumetanide: Electrolytes disturbance, GI upsets, cramps, hyperuricaemia, hyperglycaemia, gynaecomastia, blood dyscrasias, headache, dizziness, tinnitus, deafness, hypotension, cholestasis, jaundice, skin reactions, myalgia, muscle spasms, arthralgia, fatigue, acute renal failure, raised creatinine.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Potassium chloride: Acute dehydration, severe renal impairment, plasma potassium concentration >5 mmol/L, hyperkalaemia, gastric obstruction or ulceration, extensive tissue damage, metabolic acidosis. Bumetanide: Precomatose states associated with liver cirrhosis. Renal failure with anuria or oliguria. Precautions: Potassium chloride: Mild moderate renal impairment, cardiac disease, hypomagnesaemia, monitor serum electrolytes. History of peptic ulcer. Severe GI upset or haemorrhage; withdraw. Elderly. Bumetanide: Severe electrolyte depletion. Monitor electrolytes and consider supplementation if necessary. Renal or hepatic impairment, hypotension, porphyria, diabetes, gout. Prostatic hypertrophy or impaired micturition. Elderly.

Interactions

Potassium chloride: K+ -sparing diuretics, ACE inhibitors, angiotensin II receptor antagonist, NSAIDs, heparin, digoxin, B blockers, tacrolimus, aldosterone antagonists. Bumetanide: Lithium, cardiac glycosides, anti-hypertensives, aminoglycosides, NSAIDs and other nephrotoxic and ototoxic drugs.

Pharmacokinetics

POTASSIUM CHLORIDE: Absorption: Well absorbed from upper GI tract. Excretion: Urine (primarily). Skin. Faeces. BUMETANIDE: Onset of action: Oral, IM: 0.5-1 hr; IV: 2-3 min. Peak effect: Oral: 1-2 hrs; IV: 15-30 mins. Duration: Oral: 4-6 hrs; IV: 2-3 hrs. Metabolism: Partially hepatic. Bioavailability: 59%-89%. Half-life elimination: Premature and full term neonates: 6 hrs (range upto 15 hrs). Infants < 2 mth: 2.5 hrs. Infants 2-6 mth: 1.5 hrs. Adults: 1-1.5 hrs. Excretion: Urine (81%). Faeces (2%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.