Pitavastatin

Hypolipidaemic/Anti-atheroma · HMG-CoA reductase inhibitor

Indications

Hypercholesterolaemia, familial hypercholesterolaemia.

Dosage

Adults: 1-2 mg once daily, may be increased to max 4 mg/day. Hepatic impairment: 1 mg/day. Max: 2 mg. Children: Not recommended.

Adverse Effects

Abdominal pain, rash, malaise, numbness & pruritus. Rhabdomyolysis, myopathy, hepatic dysfunction, jaundice, decreased platelet count.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Hepatic disorders or biliary atresia. Precautions: Hepatic or renal disorder. Hypothyroidism, hereditary muscle disorders, history of drug-induced myopathy. Elderly: Monitor plasma lipid levels regularly.

Interactions

Cyclosporin, fibrates, niacin, cholestyramine.

Advice to Patient

Take with or without meals. Take medication at same time each day. Contact prescriber if there is unresolved muscle pain, weakness, malaise or fever. Avoid alcohol during therapy.

Pharmacokinetics

Onset: 2-4 wks. Absorption: Oral: 80%. Metabolism: Hepatic. Bioavailability: Absolute: 51%. Half-life elimination: 12 hrs. Time to peak, plasma: Oral: 1 hr. Excretion: Faeces (79%). Urine (15%).

Brands with this active ingredient

• Pit-Stat
• Pitacol
• Pitalo
• Pitava

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.