Piroxicam-beta-cyclodextrin

Anti-rheumatic, Systemic · Oxicam

Indications

Acute and chronic painful disorders: Musculo-skeletal pain (rheumatic pain, osteoarthritis, ankylosing spondylitis), post-operative pain, traumatic pain, dysmenorrhoea, headache including migraine, toothache.

Dosage

Adults: 20 mg daily as a single dose, can be increased to 40 mg daily. Elderly, Patients can be given 10 mg (half tab). Children: Not recommended.

Adverse Effects

Gl disturbances, skin reactions, oedema, CNS effects, malaise, tinnitus.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Caution advised or effect undetermined. Contraindications: Aspirin/anti-inflammatory induced allergy. Active peptic ulcer, history of recurrent ulceration. Precautions: Impaired renal or hepatic function. Monitor on long term therapy. Heart failure; elderly. Phenylketonuria.

Interactions

Anticoagulants, other NSAIDs, hypoglycaemics, lithium.

Advice to Patient

Take immediately after meals. Contact prescriber if there is severe diarrhoea, skin irritation, nausea, vomiting, dizziness, stomach upset, convulsions.

Pharmacokinetics

Absorption: Dissociates in the GI tract to piroxicam and betadex. Absorption is more rapid than that of unmodified piroxicam. Metabolism: Hepatic. Half-life elimination: 50 hrs. Time to peak, plasma: Oral: 30-60 mins. Excretion: Urine (mainly). Faeces.

Brands with this active ingredient

• Albocam
• Antixin
• Arrimax-Beta
• Arsicam
• Astecare
• Beka-20
• Bene
• Beta-1
• Beta-cyric
• Beta-Lib
• Betacare
• Betadex
• Betoxi
• Bexagen
• Bextrin

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.