Pindolol and Clopamide
Betablocking Agent · Non-cardioselective beta-blocker/Thiazide diuretic
Indications
Mild to moderate hypertension.
Dosage
Adults: Initially 1 tab in the morning increasing if necessary after 2 to 3 wk to 2 tab or max 3 tab daily. Children: Not recommended.
Adverse Effects
Bradycardia, hypotension, heart failure, increased AV block, Raynaud's phenomenon, cold extremities, sexual dysfunction. GI, sleep and CNS disturbances. Bronchospasm. Skin reactions, withdraw if unexplained dry eyes or rash. Fatigue, headache, paraesthesia, electrolyte disturbances, hyperuricaemia, gout, hyperglycaemia, hypercholesterolaemia, pancreatitis, blood dyscrasias, hypersensitivity reactions.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: 2nd or 3rd degree AV block (without pacemaker), severe bradycardia, sick sinus syndrome, uncontrolled heart failure, Prinzmetal's angina, metabolic acidosis, untreated pheochromocytoma, obstructive pulmonary disease, cor pulmonale, history of bronchospasm or asthma, prolonged fasting or refractory hypokalaemia, hyponatraemia, hypercalcaemia, Addison's disease, severe renal or hepatic impairment, symptomatic hyperuricaemia. Precautions: 1st degree AV block. Heart failure (avoid If uncontrolled), Ischaemic heart disease, withdraw gradually. History of non-asthmatic chronic obstructive lung disease. Recent Ml. Diabetes, hyperthyroidism, mild to moderate renal or hepatic impairment, psoriasis. Elderly. Consider withdrawal before elective surgery. Anaphylaxis risk due to increased…
Interactions
Lithium, Ca++ antagonists. Antihypertensives, including centrally acting agents (e.g. clonidine), antiarrhythmics, antipsychotics, TCADs, MAOIs, barbiturates, cardiac glycosides, sympathomimetics, cimetidine, hydralazine, insulin/oral hypoglycaemics, NSAIDs, anaesthetics.
Pharmacokinetics
PINDOLOL: Absorption: Completely absorbed from the GI tract. Metabolism: Partially metabolized in the liver. Bioavailability: 87%. Half-life elimination: 3-4 hrs. Prolonged in elderly hypertensive patients and in patients with renal or hepatic impairment. Time to peak, plasma: Oral: 1-2 hrs. Excretion: Urine (35%-40% as unchanged drug; 60%-65% as metabolites). IV: Faeces (6%-9%). CLOPAMIDE: Onset: 1-2 hrs. Duration: 24 hrs. Absorption: Completely absorbed from the GI tract. Metabolism: Complex. Bioavailability: 100%. Half-life elimination: 10 hrs. Time to peak, plasma: 3-6 hrs. Excretion: Renal (30%-40%).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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