Phloroglucinol and Trimethylphloroglucinol

Antispasmodic & Anticholinergic · Antispasmodic

Indications

Smooth muscle spasm.

Dosage

Adults: TABLET: 1 tab three times daily; max 6 tab daily. Children: Not recommended. INJECTION: Adults: 1-3 amp daily. Children: Not recommended.

Adverse Effects

Constipation, transient bradycardia (followed by tachycardia, palpitation and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatation of the pupils with loss of accommodation, photophobia, dry mouth, flushing and dryness of the skin. Side-effects that occur occasionally include confusion (particularly in the elderly), nausea, vomiting and giddiness. Very rarely, angle-closure glaucoma may occur.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Antimuscarinics are contra-indicated in Myasthaenia gravis (but may be used to decrease muscarinic side-effects of anticholinesterases), paralytic ileus, pyloric stenosis, toxic megacolon and prostatic enlargement. Coma, stupor, iodine sensitivity. Precautions: Antimuscarinics should be used with caution in Down's syndrome, in children and in the elderly; they should also be used with caution in gastro-esophageal reflux disease, diarrhoea, ulcerative colitis, autonomic neuropathy, acute myocardial infarction, hypertension, conditions characterised by tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), pyrexia and in individuals susceptible to angle-closure glaucoma.

Interactions

Amantadine, atenolol, digoxin, phenothiazines, tricyclic antidepressants.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.