Perindopril and Indapamide

ACE Inhibitor · ACE inhibitor/Diuretic

Indications

Hypertension in patients in adequately controlled on perindopril.

Dosage

Adults: 1 tab daily in the morning before food. Children: Not recommended.

Adverse Effects

Headache, asthaenia, dizziness, mood changes, sleep disturbance, cramps, hypotension, rash, epigastric pain, anorexia, nausea, abdominal pain, taste disturbance, cough, hypokalaemia, constipation, dry mouth, paraesthesia. Rarely angioneurotic oedema, pancreatitis, GI upset, tinnitus, visual disturbances, pruritus, dyspnoea, raised blood urea and creatinine, photosensitivity, blood dyscrasias, hypercalcaemia, myopia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: History of angioneurotic oedema associated with ACE therapy, hereditary or idiopathic angioneurotic oedema, severe renal or hepatic failure, renal artery stenosis, hyperkalaemia/hypokalaemia, hepatic encephalopathy, sulphonamide sensitivity, haemodialysis uncompensated heart failure. Precautions: Renal impairment, monitor renal function before and during treatment. Monitor serum electrolytes. Volume & electrolyte depletion. Immunosuppression. Surgery/anaesthesia. QT prolongation. Renal artery stenosis, single functioning kidney, primary aldosteronism, diabetes, severe heart failure, aortic or mitral valve stenosis, hypertrophic cardiomyopathy, hyperuricaemia, collagen vascular disease, hypotension, black race, desensitisation, LDL-apheresis with dextran sulfate. Surgery/…

Interactions

K+ sparing diuretics or K+ supplements, NSAIDs, antidiabetic agents. Baclofen, neuroleptics, tricyclic antidepressants, antihypertensives, corticosteroids, immunosuppressants, anaesthetics, drugs prolonging QT interval or causing torsade de pointes, allopurinol, antiarrhythmics, cardiac glycosides, amphotericin, laxatives, metformin, Ca++ salts, cyclosporin, baclofen, antipsychotics, TCADs, tetracosactide, digoxin, sodium aurothiomalate, mTOR inhibitors, racecadotril, iodinated contrast agents.

Advice to Patient

Take before meals.

Pharmacokinetics

PERINDOPRIL: Onset of action: Peak effect: 1-2 hrs. Metabolism: Hepatic. Bioavailability: Approx. 75%. Half-life elimination: 1.5-3 hrs. Time to peak: Chronic therapy: Approx. 1 hr. Excretion: Urine. INDAPAMIDE: Absorption: Rapid and complete. Metabolism: Extensively hepatic. Bioavailability: 93%. Half-life elimination: Biphasic: 14 and 25 hrs. Time to peak: 2 hrs. Excretion: Urine (Approx.70%). Faeces (23%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.