Paracetamol, Caffeine and Thioridazine

Non-narcotic Analgesic · Para-aminophenol derivative/Tranquilliser/Xanthine

Indications

As analgesic.

Dosage

Adults: 1 to 2 tab which may be repeated every 6 hr. Children: Not recommended.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Contains phenothiazine, avoid regular use as analgesic.

Pharmacokinetics

PARACETAMOL: Onset of action: Oral: <1 hr. IV: Analgesia: 5-10 min. Antipyretic: Within 30 min. Peak effect: IV: Analgesic: 1 hr. Duration: IV, Oral: Analgesia: 4-6 hrs. IV: Antipyretic: =6 hrs. Absorption: Primarily absorbed in small intestine, minimal absorption from stomach (varies by dosage form). Metabolism: Hepatic. Half-life elimination: Neonates: 7 hrs. Infants: Approx. 4 hrs. Children: 3 hrs. Adolescents: Approx. 3 hrs. Adults: Approx. 2 hrs. CrCl<30 mL/min: 2-5.3 hrs. Time to peak, serum: Immediate release: 10-60 min. IV: 15 min. Excretion: Urine. CAFFEINE: Metabolism: Hepatic. Half-life elimination: Neonates: 72-96 hrs. Children >9 mths and Adults: 5 hrs. Time to peak, serum: Oral: Within 30 mins-2 hrs. Excretion: Neonates =1 mth: 86% excreted unchanged in urine. Infants >1 mth and Adults: In urine, as metabolites. THIORIDAZINE: Onset: Tab: 30-60 mins. Duration: 4-6…

Compiled by Healify Pharmacy from published drug references. How we compile it →

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