Paracetamol and Vitamin B1, B6 and B12

Non-narcotic Analgesic · Para-aminophenol derivative/Vitamin

Indications

Neuralgia and neuritis of toxic and non-toxic origin.

Dosage

Adults: 3 tab daily. Children: Not recommended.

Adverse Effects

Cyanosis, skin eruptions, hypoglycaemia, CNS stimulations. Inj: Hypotension, flushing and tachycardia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Precautions: Impaired hepatic function.

Interactions

Drugs which delay gastric emptying (e.g. anticholinergics, narcotics).

Pharmacokinetics

PARACETAMOL: Onset of action: Oral: <1 hr. IV: Analgesia: 5-10 min. Antipyretic: Within 30 min. Peak effect: IV: Analgesic: 1 hr. Duration: IV, Oral: Analgesia: 4-6 hrs. IV: Antipyretic: =6 hrs. Absorption: Primarily absorbed in small intestine, minimal absorption from stomach (varies by dosage form). Metabolism: Hepatic. Half-life elimination: Neonates: 7 hrs. Infants: Approx. 4 hrs. Children: 3 hrs. Adolescents: Approx. 3 hrs. Adults: Approx. 2 hrs. CrCl<30 mL/min: 2-5.3 hrs. Time to peak, serum: Immediate release: 10-60 min. IV: 15 min. Excretion: Urine. VITAMIN B1: Absorption: Oral: Small amounts are well absorbed from GI tract. Limited absorption for doses > 5 mg. IM: Rapid absorption. Metabolism: Hepatic. Bioavailability: 3.7%-5.3%. Excretion: Urine. VITAMIN B6: Absorption: Readily absorbed from the GI tract. Metabolism: Hepatic. Half-life elimination: 15-20 days. Time to peak:…

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.