Paracetamol and Caffeine

Non-narcotic Analgesic · Para-aminophenol derivative/Xanthine

Indications

Headache, migraine, backache, rheumatic and muscle pains, neuralgia.

Dosage

Adults: 2 tab up to 4 times daily, should not be repeated more frequently than 4 hr. Max 8 tab daily. Children: Not recommended.

Adverse Effects

Cyanosis, skin eruptions, hypoglycaemia, CNS stimulations. Inj: Hypotension, flushing and tachycardia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Precautions: Impaired hepatic function.

Interactions

Drugs which delay gastric emptying (e.g. anticholinergics, narcotics).

Advice to Patient

Place disintegrating tablet on tongue and let it dissolve. Do not swallow whole. Contact prescriber if there is difficulty in breathing, swelling on face/lips/tongue/throat, rash, loss of appetite, abdominal pain, low fever with nausea, dark urine, dark stools, yellowing of the skin or eyes. Avoid alcohol during therapy. Avoid drinks that contain caffeine.

Pharmacokinetics

PARACETAMOL: Onset of action: Oral: <1 hr. IV: Analgesia: 5-10 min. Antipyretic: Within 30 min. Peak effect: IV: Analgesic: 1 hr. Duration: IV, Oral: Analgesia: 4-6 hrs. IV: Antipyretic: =6 hrs. Absorption: Primarily absorbed in small intestine, minimal absorption from stomach (varies by dosage form). Metabolism: Hepatic. Half-life elimination: Neonates: 7 hrs. Infants: Approx. 4 hrs. Children: 3 hrs. Adolescents: Approx. 3 hrs. Adults: Approx. 2 hrs. CrCl<30 mL/min: 2-5.3 hrs. Time to peak, serum: Immediate release: 10-60 min. IV: 15 min. Excretion: Urine. CAFFEINE: Metabolism: Hepatic. Half-life elimination: Neonates: 72-96 hrs. Children >9 mths and Adults: 5 hrs. Time to peak, serum: Oral: Within 30 mins-2 hrs. Excretion: Neonates =1 mth: 86% excreted unchanged in urine. Infants >1 mth and Adults: In urine, as metabolites.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.