Ozagrel

Anticoagulant/Antiplatelet · Thromboxane synthetase inhibitor

Indications

For the treatment of acute thrombotic cerebral infarction or disturbance in motor functions.

Dosage

Adults: 80 mg, twice a day, solute in 500 mL normal saline or 5% glucose solution, IV infusion, treatment duration is 2 wk. Children: Not recommended.

Adverse Effects

Because of bleeding tendency, careful observation is needed. Stop the administration once such abnormal symptom appears. Occasional increase of GOT, GPT, BUN. Digestive system: Occasional nausea, vomiting, diarrhoea, anorexia, abdominal distension. Occasional urticaria, skin rash, etc., stop the administration once such effects spotted. Occasional supraventricular arrhythmia and hypotension, once such symptom appears, decrease the amount or stop the administration. Occasional headache, fever, pain at the injection site, shock or thrombocytopenia. Severe adverse effects can be haemorrhagic cerebral infarction, extradural haemorrhage, encephalic haemorrhage, gastrointestinal haemorrhage, subcutaneous haemorrhage.

Risk Factor (Pregnancy/Lactation)

Contraindications: Cerebral haemorrhage or cerebral infarction with haemorrhage, deep coma accompanied large area cerebral infarction, severe impairment of heart, lung, liver, kidney, such as severe arrhythmia or cardiovascular infarction. Hemopathy or hemorrhagic tendency. Severe hypertension, with a contracting pressure of 200 mmHg.

Pharmacokinetics

Metabolism: Hepatic. Half-life elimination: IV: <2 hrs.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.