Orphenadrine, Paracetamol and Caffeine

Muscle Relaxant · Central anticholinergic (skeletal muscle relaxant)/Para-aminophenol derivative/Xanthine

Indications

Acute and chronic painful muscular conditions, non-articular rheumatism.

Dosage

Adults: 1 tab 3 times daily. Children: Not recommended.

Adverse Effects

Dry mouth, nausea, blurred vision, dizziness, confusion, tremor.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Glaucoma, urinary retention, Myasthaenia gravis. Precautions: Tachycardia.

Advice to Patient

Avoid alcohol during therapy. Contact prescriber if there is fast heartbeat, dry mouth, blurred vision, nausea, vomiting, headache, dizziness, severe constipation.

Pharmacokinetics

ORPHENADRINE: Onset: 1 hr. Duration: 4-6 hrs. Absorption: Oral: Readily absorbed from the GI tract. Metabolism: Hepatic. Half-life elimination: 14 hrs. Time to peak, plasma: 2-4 hrs. Excretion: Urine (mainly). PARACETAMOL: Onset of action: Oral: <1 hr. IV: Analgesia: 5-10 min. Antipyretic: Within 30 min. Peak effect: IV: Analgesic: 1 hr. Duration: IV, Oral: Analgesia: 4-6 hrs. IV: Antipyretic: =6 hrs. Absorption: Primarily absorbed in small intestine, minimal absorption from stomach (varies by dosage form). Metabolism: Hepatic. Half-life elimination: Neonates: 7 hrs. Infants: Approx. 4 hrs. Children: 3 hrs. Adolescents: Approx. 3 hrs. Adults: Approx. 2 hrs. CrCl<30 mL/min: 2-5.3 hrs. Time to peak, serum: Immediate release: 10-60 min. IV: 15 min. Excretion: Urine. CAFFEINE: Metabolism: Hepatic. Half-life elimination: Neonates: 72-96 hrs. Children >9 mths and Adults: 5 hrs. Time to…

Compiled by Healify Pharmacy from published drug references. How we compile it →

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