Omeprazole , Sodium bicarbonate and Magnesium hydroxide

Antipeptic Ulcerant · Antacid/Proton pump inhibitor

Indications

Oesophageal reflux disease, reflux oesophagitis. Long-term management of acid-reflux disease. Duodenal and benign gastric ulcers including those complicating NSAID therapy. Duodenal ulcers associated with H. pylori. Zollinger-Ellison syndrome. Prophylaxis of acid aspiration during general anaesthesia.

Dosage

The dosage mentioned are calculated on the basis of Omeprazole in the product contents. Reflux oesophagitis: Adults: 20 mg once daily for 4 wk, extend for a further 4-8 wk if not fully healed. Refractory cases, 40 mg once daily. Acid-reflux disease: Adults: Long-term management, 10 mg once daily, increasing to 20 mg once daily if symptoms return. Duodenal ulcer: Adults: 20 mg once daily for 4 wk. Severe cases, increase to 40 mg once daily. Prevention of relapse, 20 mg once daily, dose may range between 10 mg to 40 mg daily. DU with H. pylori: Adults: 40 mg daily with amoxicillin 1.5-2 gm daily for 2 wk. Gastric ulcer: Adults: 20 mg once daily for 8 wk. Severe cases, increase to 40 mg once daily. Zollinger-Ellison syndrome: Adults: 60 mg once daily adjusted to response. Usual maintenance, 20-120 mg daily. Doses over 80 mg daily, give in two divided doses. Acid aspiration: Adults: 40 mg…

Adverse Effects

Headache, GI upset, skin rashes, paraesthesia, dizziness, somnolence, insomnia, arthralgia, myalgia. Increased risk of GI infections. Increase in liver enzymes.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Precautions: Exclude malignancy before treatment. Hepatic impairment. Monitor serum B12 in severely ill children on long term treatment.

Interactions

Diazepam, phenytoin, warfarin, digoxin, ketoconazole, itraconazole.

Pharmacokinetics

OMEPRAZOLE: Onset of action: Approx. 1 hr. Peak effect: Within 2 hrs. Duration: Up to 72 hrs. Maximum secretory inhibition: 4 days. Absorption: Rapid. Metabolism: Hepatic. Bioavailability: Oral: Approx. 30%-40%. Hepatic dysfunction: Approx. 100%. Half-life elimination: 0.5-1 hr. Hepatic impairment: Approx. 3 hrs. Time to peak, plasma: 0.5-3.5 hrs. Excretion: Urine, faeces. SODIUM BICARBONATE: Onset of action: Oral: 15 min. IV: Rapid. Duration: Oral: 1-3 hrs. IV: 8-10 min. Absorption: Oral: Well absorbed. Excretion: Urine. MAGNESIUM HYDROXIDE: Onset of action: 0.5-3 hrs. Duration: Variable. Absorption: About 15%-50% is absorbed very slowly through the small intestine. Metabolism: Does not undergo metabolism. Excretion: Urine (absorbed portion of drug). Faeces, saliva (unabsorbed portion of drug).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.