Olmesartan Medoxomil and Hydrochlorothiazide

Angiotensin-II Antagonist · Angiotensin II antagonist/Thiazide diuretic

Indications

Hypertension in patients whose BP is not adequately controlled by olmesartan alone.

Dosage

Adults: 1 tab daily. Titrate dose after 2-4 wks if necessary. Children: Not recommended.

Adverse Effects

Dizziness, fatigue, headache, confusion, asthaenia, peripheral oedema, pain, glucosuria, bronchitis, cough, pharyngitis, rhinitis, GI upset, haematuria, UTI, flu-like symptoms, electrolyte disturbances, raised creatine kinase and urea.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Hepatic or severe renal impairment, cholestasis, biliary obstructive disorders, refractory hypokalaemia, hypercalcaemia, hyponatraemia, symptomatic hyperuricaemia, primary aldosteronism. Precautions: Salt or volume depletion, severe congestive heart failure, renal disease, renal artery stenosis, aortic or mitral valve stenosis, obstructive hypertrophic cardiomyopathy, kidney transplant, asthma, SLE, gout, primary aldosteronism, diabetes. Mild to moderate renal impairment; monitor serum electrolytes, creatinine and uric acid. Risk of sprue-like enteropathy (discontinue).

Interactions

Lithium, K-supplement, K+-sparing diuretics, salt substitutes, baclofen, NSAIDs, amifostine, alcohol, CNS depressants, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G, salicylic acid derivatives, calcium supplement, cholestyramine, colestipol, cardiac glycosides, drugs prolonging QT interval or causing torsade de pointes, tubocurarine, anticholinergics, antidiabetic agents, metformin, beta-blockers, diazoxide, uricosuric agents, other antihypertensives, antidepressants, benzylpenicillin, other drugs affected by serum K+ disturbances, muscle relaxants, allopurinol, sympathomimetics, amantadine, cytotoxics, cyclosporin, tetracyclines.

Advice to Patient

Take with or without meals.

Pharmacokinetics

OLMESARTAN: Metabolism: GI tract. Bioavailability: 26%. Half-life elimination: Terminal: 13 hrs. Time to peak: 1-2 hrs. Excretion: Faeces (50%-65%). Urine (35%-50%). HYDROCHLOROTHIAZIDE: Onset of action: Diuresis: Infants: 2-6 hrs. Adults: Approx. 2 hrs. Peak effect: 4-6 hrs. Duration: Infants: 8 hrs. Adults: 6-12 hrs. Absorption: Well absorbed, absorption is decreased in patients with CHF. Metabolism: Not metabolized. Bioavailability: 65%-75%. Half-life elimination: Approx. 6-15 hrs. Time to peak: Approx. 1-5 hrs. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.