Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide

Angiotensin-II Antagonist · Angiotensin II antagonist/Calcium antagonist/Thiazide diuretic

Indications

Hypertension, reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarction. It is used as add-on/switch therapy to provide additional blood pressure lowering for patients not adequately controlled on agents from two of the following antihypertensive classes: angiotensin receptor blockers, calcium channel blockers, and diuretics at their maximally tolerated, labeled or usual dose. Not indicated for initial therapy.

Dosage

Adults: One tab of 20/5/12.5 mg once daily. Dosage may be increased after 2 wks to a max dose of 40/10/25 mg once daily, usually by increasing one component at a time.

Adverse Effects

Dizziness, peripheral oedema, headache, fatigue, nasopharyngitis, muscle spasms, nausea, upper RTIs, diarrhoea, UTI, joint swelling.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Anuria. Severe renal impairment (CrCl=30 mL/min). Severe hepatic impairment. Precautions: Volume or salt-depleted patients. Mild to moderate hepatic impairment.

Interactions

Aliskiren (avoid co-administration in patients with diabetes). NSAIDs, simvastatin, barbiturates, narcotics, cholestyramine, colestipol, corticosteroids, ACTH, lithium.

Advice to Patient

Take with meals. Avoid alcohol during treatment. Lie down if you feel faint or dizzy. Inform prescriber if you experience swelling in feet/ankles/hands, unexplained weight gain, dry mouth, unusual thirst, weakness, tiredness/sleepness/restlessness, confusion, seizures, muscle pain/cramps/tiredness, dizziness/faintness, low or no urine output, fast heartbeat, nausea, vomiting, headache, diarrhea, eye pain, decrease in vision.

Pharmacokinetics

OLMESARTAN: Metabolism: GI tract. Bioavailability: 26%. Half-life elimination: Terminal: 13 hrs. Time to peak: 1-2 hrs. Excretion: Faeces (50%-65%). Urine (35%-50%). AMLODIPINE: Onset of action: Antihypertensive effect: Significant reductions in blood pressure at 24-48 hrs after first dose. Duration: Antihypertensive effect: At least 24 hrs. Discontinuation after 6-7 wks of treatment: Duration extends to at least 72 hrs. Absorption: Well absorbed. Metabolism: Hepatic. Bioavailability: 64%-90%. Half-life elimination: Terminal (biphasic): 30-50 hrs. Time to peak, plasma: 6-12 hrs. Excretion: Urine. HYDROCHLOROTHIAZIDE: Onset of action: Diuresis: Infants: 2-6 hrs. Adults: Approx. 2 hrs. Peak effect: 4-6 hrs. Duration: Infants: 8 hrs. Adults: 6-12 hrs. Absorption: Well absorbed, absorption is decreased in patients with CHF. Metabolism: Not metabolized. Bioavailability: 65%-75%.…

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.