Nebivolol and Valsartan

Betablocking Agent · Angiotensin II antagonist/Beta-blocker

Indications

Hypertension.

Dosage

Adults: 1 tab once daily. Children: Not recommended.

Adverse Effects

Slow heartbeat. Increased serum Potassium. Vertigo.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe bradycardia. Heart block > 1st degree. Cardiogenic shock. Decompensated cardiac failure. Sick sinus syndrome (unless a permanent pacemaker is in place). Severe hepatic impairment (Child-Pugh>B). Diabetes. Severe renal impairment. Precautions: Do not abruptly discontinue. Monitor glucose as beta-blocker may mask symptoms of hypoglycaemia. Monitor renal function and potassium in susceptible patients. Hyperthyroidism. Peripheral vascular disease. In patients with known or suspected pheochromocytoma, initiate alpha-blocker prior to the use of any beta-blocker.

Interactions

CYP2D6 enzyme inhibitors (e.g. Quinidine, Propafenone, Fluoxetine, Paroxetine). Reserpine. Guanethidine. Clonidine. Digitalis glycosides. Verapamil- or diltiazem-type Calcium channel blockers. Potassium sparing diuretics, potassium supplements or salt substitutes. NSAIDs. Lithium. Aliskiren (do not co-adm in case of diabetes or renal impairment (GFR <60 mL/min). Mavorixafor. Sparsentan.

Advice to Patient

Take with or without meals. Lightheadedness can occur, esp during the first days of therapy. Report to prescriber. Take sufficient fluids to prevent dehydration and low BP. Do not use salt substitutes containing potassium without consulting prescriber.

Pharmacokinetics

NEBIVOLOL: Absorption: Oral: Rapid. Metabolism: Hepatic. Bioavailability: Fast metabolizers: 12%. Slow metabolizers: Complete. Half-life elimination: Fast metabolizers: 10 hrs. Hydroxy metabolites: 24 hrs. Excretion: Urine (38%). Faeces (48%). VALSARTAN: Onset of action: Approx. 2 hrs. Duration: 24 hrs. Metabolism: To inactive metabolite. Bioavailability: Tab: 25%. Susp: Approx. 40%. Half-life elimination: Children 1-5 yrs: Approx. 4 hrs. 6-16 yrs: Approx. 5 hrs. Adults: Approx. 6 hrs. Time to peak, serum: Children 1-16 yrs: Oral susp: 2 hrs. Adults: 2-4 hrs. Excretion: Faeces (83%). Urine (13%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.