Mycophenolate

Immunomodulator · Immunosuppressant

Indications

With cyclosporin and corticosteroids for prophylaxis of acute rejection in allogeneic renal, cardiac or hepatic transplants.

Dosage

Adults: Renal transplants: 1 gm twice daily starting within 72 hr of transplant. Cardiac transplants: 1.5 gm twice daily starting within 5 days of transplant. Hepatic transplants: 1.5 gm twice daily following intravenous therapy. Children: Under 2 yr, not recommended; 2-18 yr, 600 mg/m² twice daily, up to max 2 gm daily.

Adverse Effects

Gl upset, blood dyscrasias, infections, hypertension, metabolic and CNS disturbances, respiratory disorders, colitis, pancreatitis, intestinal villous atrophy.

Risk Factor (Pregnancy/Lactation)

Contraindications: Pregnancy, lactation. Precautions: Monitor full blood counts regularly. GI disease, hereditary HGPRT deficiency. Elderly.

Interactions

Acyclovir, valaciclovir, ganciclovir, antacids, azathioprine, cholestyramine, probenecid, vaccines, tacrolimus.

Pharmacokinetics

Absorption: Rapid and complete. Metabolism: Hepatic. Half-life elimination: Oral: 17.9 ± 6.5 hrs. IV: 16.6 ± 5.8 hrs. Time to peak: MPA (active metabolite): 60-90 mins. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.