Misoprostol

Antipeptic Ulcerant · Prostaglandin

Indications

Benign gastric and duodenal ulceration and NSAID associated ulceration. Prophylaxis of NSAID-induced gastric and duodenal ulcer.

Dosage

Adults: Benign gastric and duodenal ulceration and NSAID associated ulceration: 800 mcg daily in 2-4 divided doses with breakfast or main meals and at bedtime; treatment should be continued for at least 4 wk and may be continued for up to 8 wk if required. Prophylaxis of NSAID-induced gastric and duodenal ulcer: 200 mcg 4 times daily (if not tolerated, reduced to 200 mcg 2-3 times daily, but less effective). Children: Not recommended.

Adverse Effects

Diarrhoea (may occasionally be severe and require withdrawal, reduced by giving single doses not exceeding 200 mcg and by avoiding magnesium-containing antacids); abdominal pain, dyspepsia, flatulence, nausea and vomiting, abnormal vaginal bleeding (including intermenstrual bleeding, menorrhagia and post-menopausal bleeding), rashes, dizziness.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Women of childbearing age. Precautions: Conditions where hypotension might precipitate severe complications (e.g. cerebrovascular disease, cardiovascular disease).

Interactions

Antacids.

Advice to Patient

Take with meals or after meals. Take with meals when used for the prophylaxis of NSAID-induced ulcers. Last dose of the day should be taken before sleeping. Contact prescriber if diarrhoea lasts more than 8 days. During therapy NSAIDs can be taken, if prescribed. Do not take Magnesium containing antacids.

Pharmacokinetics

Onset of action: 30 min. Duration of action: 3 hrs. Absorption: Rapid and extensive. Metabolism: Hepatic. Half-life elimination: 20-40 min. Time to peak, serum: Fasting: 12 ± 3 min. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.