Lynestrenol

Progestogen · Progestogen

Indications

Disturbance of menstrual cycle.

Dosage

Adults: Disturbance of menstrual cycle: 1 tab daily on days 14-25 of the cycle. The first day of the cycle is the first day of menstruation. Children: Not recommended.

Adverse Effects

Transient infertility on continuous treatment, irregular, prolonged or heavy vaginal bleeding during first 2 or 3 cycles. Back pain, weight gain, fluid retention.

Risk Factor (Pregnancy/Lactation)

Contraindications: Progestogens should be avoided in patients with a history of liver tumours, with genital or breast cancer (unless progestogen are being used in the management of these conditions), severe arterial disease, undiagnosed vaginal bleeding and acute porphyria. Progestogens should not be used if there is a history during pregnancy of idiopathic jaundice, severe pruritus, or pemphigoid gestations. Precautions: Progestogens should be used with caution in conditions that may worsen with fluid retention e.g. epilepsy, hypertension, migraine, asthma, or cardiac dysfunction and in those susceptible to thromboembolism (particular caution with high dose, history of depression. Progestogens can decrease glucose tolerance and patients with diabetes should be monitored closely.

Interactions

Rifamycin, anticoagulants, antidepressants, antidiabetics, anti-epileptics, antifungals, antivirals, aprepitant, barbiturates, bosentan, cyclosporin, diuretics, dopaminergics, lipid-regulating drugs, muscle relaxants.

Pharmacokinetics

Absorption: Rapid. Metabolism: Lynestrenol is converted into active metabolite norethisterone (NET). NET is further reduced. Bioavailability: NET: Absolute: 64%. Half-life elimination: NET: Approx. 15 hrs. Time to peak, plasma: 2-4 hrs. Excretion: Urine and faeces (in ratio of 1.5:1).

Brands with this active ingredient

• Minipyl
• Omatril

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.