Lormetazepam

Tranquilizer, Sedative/Hypnotic · Benzodiazepine

Indications

Sleep disturbances.

Dosage

Adults: 1 tab at bed time. Children: Not recommended.

Adverse Effects

Drowsiness, which may continue into the following day. Muscle weakness, ataxia, confusion, vertigo, GI upset, visual disturbances, rash, impaired alertness and dexterity, headache, urinary retention, changes in libido. Anterograde amnesia. Rarely blood disorders, jaundice. Dependence.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Acute pulmonary insufficiency, respiratory depression, sleep apnoea, phobic or obsessional states, chronic psychosis, Myasthaenia gravis. Severe hepatic impairment. As monotherapy to treat depression or anxiety associated with depression. Precautions: Chronic pulmonary insufficiency. Renal impairment. Mild to moderate hepatic impairment. History of drug or alcohol abuse. Personality disorders. Elderly. Avoid long-term use. Withdraw gradually.

Interactions

Alcohol, CNS depressants, anticonvulsants, CYP3A4 inhibitors or inducers (e.g. cimetidine, rifampicin).

Advice to Patient

Take immediately before bedtime. Avoid prolonged use. Avoid alcohol during therapy. Contact prescriber if there is increased confusion, feeling of unsteadiness or forgetfulness.

Pharmacokinetics

Absorption: Oral: Rapidly absorbed from the GI tract. Metabolism: Hepatic. Bioavailability: 80%. Half-life elimination: Terminal: 11 hrs. Time to peak, plasma: Oral: 1.5 hrs. Excretion: Urine (86%).

Brands with this active ingredient

• Gtvan
• Lortem
• Meteeza
• Noctamid

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.