Lisuride

Antiparkinsonism Preps · Dopamine agonist

Indications

As dopamine agonist in: Parkinson's disease post encephalitic Parkinsonism, Parkinsonism of other genesis (with the exception of the drug-induced form). As prolactin inhibitor in: Primary and secondary ablactation (where medically indicated), mastitis, galactorrhoea; reduction of excessive milk production (postpartum galactostasis); prolactin-induced amenorrhoea; other prolactin-related cycle disturbances (e.g. luteal insufficiency); prolactin-induced infertility of the women; hyperprolactinaemic disturbances of libido or potency of the man (e.g. secondary to pituitary tumours); premenstrual complaints associated with elevated prolactin levels (e.g. mastodynia); acromegaly.

Dosage

Adults: Parkinsonism: Initially half a tab (0.1 mg) in the evening and should be increased by half a tablet weekly until a clinical effect becomes apparent. The daily dose lies between 0.6 mg and 2 mg, divided into 3 to 4 smaller doses. Primary ablactation: Treatment should be initiated, if possible, immediately after delivery or abortion, but certainly within the first 24 hr. 2-3 times daily 0.2 mg during 14 days. Secondary ablactation, mastitis: 1st day, 0.2 mg in the evening; 2nd day, 0.2 mg midday & evening; 3rd day to max 14th day, 0.2 mg morning, midday, evening. See literature. Children: Not recommended.

Adverse Effects

Nausea, headaches, tiredness, dizziness, drowsiness, sweating. Sudden decrease of blood pressure. Nightmares, hallucinations, paranoid reactions and states of confusion may occur, but almost only in patients with Parkinsonism.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Contraindications: Severe disorders of arterial circulation in the periphery and heart (coronary failure). In patients with past or present psychosis.

Interactions

Neuroleptics and other dopamine antagonists (e.g. haloperidol, sulpiride, metoclopramide, chlorpromazine). Ergot alkaloids (e.g. methyl ergometrine).

Pharmacokinetics

Absorption: Rapid. Bioavailability: 100 mcg dose: 10%. 300 mcg dose: 22%. Half-life elimination: Oral: 2.2 hrs. IV: 2 phases. 14 mins and 1.5 hrs. Time to peak, plasma: SC: 12 mins. IM: 15 mins.

Compiled by Healify Pharmacy from published drug references. How we compile it →

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