Lincomycin

Macrolide & similar types · Lincosamide

Indications

Infections caused by gram-positive pathogens.

Dosage

CAPSULE: Adults: 500 mg three or four times daily. SYP/SUSP: Children: Under 1 mth, not recommended; 1-6 mth, 1.25-2.5 mL three times daily; 6 mth-2 yr, 2.5-5 mL three times daily; 3-9 yr; 2.5-5 mL four times daily; 10-12 yr, 5-10 mL four times daily. INJECTION: Adults: 600 mg by IM inj 12-24 hrly or IV infusion 8-12 hrly. Children: Under 1 mth, not recommended; others, 10 mg/kg by IM inj 12-24 hrly; alternatively 10-20 mg/kg daily by IV infusion in 2 or 3 divided doses at 8-12 hr intervals.

Administration

IV: 1 gm Lincomycin diluted in not less than 100 mL of appropriate solution and infused over a period of not less than one hour. Reconstitution: Dilute 600 mg dose in at least 100 mL D5W, D10W, NS, dextrose 5% in NS, or other compatible diluent. Dilute higher doses in 100 mL of a compatible diluent for each gm being given. Compatibility: D5W D10W, D5NS, D10NS. Ringer's sol. Incompatible with novobiocin and kanamycin. Stability: Store at 20°C-25°C (68°F-77°F). Diluted lincomycin in an appropriate solution is physically compatible for 24 hours at room temperature unless otherwise indicated.

Adverse Effects

Persistent diarrhoea, colitis; discontinue immediately.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Clindamycin or lincomycin sensitivity. Precautions: Renal, hepatic, endocrine or metabolic disorders. Check liver function and blood regularly with prolonged use.

Interactions

Neuromuscular blocking drugs.

Advice to Patient

Take 1 hour before or 2 hours after meals, with a full glass of water. Contact prescriber if there is difficulty in breathing, chest tightness, severe diarrhoea that remains for 3 or more days, rash or if there is worsening of condition or no improvement. Watery or bloody stools can occur 2 or more months after therapy and can be serious, requiring immediate treatment.

Pharmacokinetics

Absorption: 20%-35% of an oral dose is rapidly absorbed from the GI tract. Food reduces the rate and extent of absorption. Metabolism: Hepatic (partially). Half-life elimination: 5 hrs. Prolonged in hepatic/renal impairment. Time to peak, plasma: Oral: 2-4 hrs. IM: 1 hr. IV: 2 hrs. Excretion: Urine. Faeces.

Brands with this active ingredient

• Amlin
• Asteco
• Camyan
• Comcin
• DDS Lincomycin
• Enconmycin
• Ibucin
• Licoxin
• Ligon
• Lincin
• Linco-Plus
• Lincoax
• Lincobect
• Lincobiotic
• Lincoceena

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.