Lignocaine and Prilocaine

Anaesthetic · Local anaesthetic

Indications

Surface anaesthesia of the skin in conjunction with needle insertion and for superficial surgical procedures. Surface anaesthesia of leg ulcers prior to cleaning and superficial surgical procedures, for example removal of fibrin, pus and necroses. Surface anaesthesia of the genital mucosa.

Dosage

See literature.

Adverse Effects

Local paleness, redness, oedema at application site. Slight burning sensation, itching, allergic reactions, methaemoglobinaemia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Controlled studies shown no risk. Lactation: Caution advised or effect undetermined. Contraindications: Methaemoglobinaemia. Premature infants. Precautions: Caution when using near the eyes, as this cream causes corneal irritation. Caution when using on areas on skin with atopic dermatitis. This cream should not be used on damaged tympanic membrane or in other situations where penetration into the middle ear may occur. Cream should not be applied to open wounds. This cream should also not be used on the genital mucosa in children.

Interactions

Methaemoglobin-induced preparations (e.g. sulpha preparations), local anaesthetics.

Pharmacokinetics

Absorption: Dependent on the duration of exposure and area of application. Metabolism: Hepatic. Time to peak, plasma: Patch: 2-6 hrs. Excretion: Lignocaine: Urine (<10%). Prilocaine: Urine (<5%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.