Lignocaine

Anaesthetic · Local anaesthetic

Indications

As local anaesthesia.

Dosage

INJECTION: Adults: Initial: 50-100 mg IV given 25-50 mg/min, may repeat after 5 min. Max: 200-300 mg/hr. Following bolus, initiate with 1-4 mg/min continuous infusion. Maint: Adjust according to cardiac rhythm & toxicity. Children: 1 mg/kg bolus, then 30 mcg/kg/min. TOPICAL: Apply to affected area as needed; max 3 mg/kg/dose; do not repeat within 2 hr.

Administration

IM: In deltoid muscle only. IV: Administered by direct IV injection and continuous IV infusion. Product containing 40, 100, or 200 mg/mL should not be administered by direct IV injection without prior dilution. Usually 1 or 2 gm of lignocaine is added to 1000 mL of dextrose 5% to form a 1 or 2 mg/mL (0.1 or 0.2 %) solution. Compatibility: Dextrose 5%, or with NaCl 0.45%, NaCl 0.9%. Stability: Stored at room temperature and protect from heat and freezing.

Adverse Effects

Dizziness, confusion, convulsions, respiratory depression, cardiac arrest, paraesthesia, drowsiness, bradycardia, allergic reactions.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Complete heart block, hypovolaemia. Precautions: Renal, hepatic impairment, hypotension, severe shock, epilepsy, Myasthaenia gravis, respiratory impairment, elderly, porphyria. Sinus bradycardia or any form of heart block.

Interactions

Propranolol, cimetidine, antiarrhythmics, diuretics, suxamethonium, quinupristin/dalfopristin, protease inhibitors, dolasetron.

Pharmacokinetics

Onset of action: Single bolus dose: 45-90 seconds. Duration: 10-20 mins. Metabolism: 90% hepatic. Half-life elimination: Biphasic: Prolonged with congestive heart failure, liver disease, shock, severe renal disease; Initial: 7-30 mins; Terminal: Infants, premature: 3.2 hrs, Adults: 1.5-2 hrs. Excretion: Urine (<10% as unchanged drug, approx. 90% as metabolites).

Brands with this active ingredient

• Anacaine
• Anscon
• Astelig
• Bacimix
• Baligno
• Donligno
• Epinum
• Epocain
• Healit
• Licain
• Lidocane
• Lidocip
• Lidoject
• Lidonex
• Lidosporin

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.