Levosulpiride

Antiemetic & Gastroprokinetic · Antipsychotic

Indications

Used as a gastroprokinetic, indicated in nausea and vomiting. Dyspepsia, vertigo, IBS. Schizophrenia. Tourette's syndrome. Depression with or without anxiety.

Dosage

Adults: 50-200 mg daily. Schizophrenia: Adults: Initially 200-400 mg twice daily, increase if necessary up to max 1.2 gm twice daily in patients with mainly positive symptoms or up to a total of 800 mg daily in patients with mainly negative symptoms, with neither predominating, are given usual dosage to 400-600 mg twice daily. Children: 3-5 mg/kg daily to children over 14 yr of age. Tourette's syndrome: Adolescents: 14-18 yr, 200-400 mg twice daily.

Adverse Effects

Sleep disturbances, over stimulation and agitation. Extrapyramidal effects. Cardiovascular effects, hypotension.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Comatose states, CNS depression, pheochromocytoma. Precautions: Should be given with care to manic or hypomanic patients in whom it may exacerbate symptoms.

Interactions

Alcohol, CNS depressants, guanethidine, anticholinergics, antacids, NSAIDs.

Pharmacokinetics

Absorption: Slow. Metabolism: Not metabolized. Bioavailability: Low (25%-40%; subject to interindividual variation). Half-life elimination: 8-9 hrs. Time to peak, plasma: 3-6 hrs. Excretion: Urine. Faeces.

Brands with this active ingredient

• Lopritac

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.