Levocetirizine and Montelukast

Antihistamine, Systemic · Leukotriene antagonist/R-enantiomer of cetirizine

Indications

Seasonal and perennial allergic rhinitis. Chronic idiopathic urticaria.

Dosage

Tab: Adults: 1 tab daily. Syp: Children: Under 6 yr, not recommended; 6-12 yr: 5-10 mL once daily.

Adverse Effects

Somnolence, dry mouth, fatigue, rhinitis, migraine, abdominal pain, headache, thirst, rarely anaphylaxis, angioedema, seizure, elevated ALT/AST, cholestatic hepatitis, Churg-Strauss syndrome.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe renal impairment. Precautions: Renal impairment. Discontinue if symptoms of Churg-Strauss syndrome appear.

Interactions

Phenobarbital, phenytoin, rifampicin.

Pharmacokinetics

LEVOCETRIZINE: Absorption: Rapid and extensive. Metabolism: Hepatic. Half-life elimination: 8-9 hrs. Time to peak, plasma: Oral: 0.9 hr. Excretion: Urine (85.4%). Faeces (12.9%). MONTELUKAST: Duration: >24 hrs. Absorption: Rapid. Metabolism: Extensively hepatic. Bioavailability: Tab: 10 mg, Mean: 64%; Chewable tab: 5 mg: 73% (63% when administered with a standard meal). Half-life elimination: 2.7-5.5 hrs; Mild-to-moderate hepatic impairment: 7.4 hrs. Time to peak: Tab: 10 mg: 3-4 hrs (fasting); Chewable tab: 4 mg (children 2-5 yrs): 2 hrs (fasting); Chewable tab 5 mg: 2-2.5 hrs (fasting); Granules: 2.3 ± 1 hrs (fasting) and 6.4 ± 2.9 hrs (with high-fat meal). Excretion: Faeces (86%). Urine (<0.2%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

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