Levocarnitine

Amino Acid Solution · Aminoacid

Indications

Acute and chronic treatment of patients with an inborn error of metabolism which results in secondary carnitine deficiency; prevention and treatment of carnitine deficiency in patients with end-stage renal disease (ESRD) who are undergoing haemodialysis.

Dosage

Adults and children: Metabolic disorders: 50 mg/kg as a slow 2- to 3-min IV bolus or by IV infusion. Severe metabolic crisis: A loading dose of 50 mg/kg over 2-3 min followed by an equivalent dose over the following 24 hr administered as every 3 hr or every 4 hr (never less than every 6 hr either by infusion or by IV injection). All subsequent daily doses are recommended to be in the range of 50 mg/kg or as therapy may require the highest dose administered which has been 300 mg/kg. It is recommended that a plasma carnitine concentration be obtained prior to beginning parenteral therapy accompanied by wkly and monthly monitoring. End-stage renal disease patients on haemodialysis: Predialysis levocarnitine concentrations below normal (40-50 micro mol/L): 10-20 mg/kg dry body weight as a slow 2- to 3-min bolus after each dialysis session. Dosage adjustments should be guided by predialysis…

Administration

Haemodialysis patients: Administered over 2-3 min into the venous line after each dialysis.

Adverse Effects

Hypertension, peripheral oedema. Dizziness, fever, paresthesia, depression. Hypercalcaemia. Diarrhoea, abdominal pain, vomiting, nausea. Weakness. Allergic reaction.

Risk Factor (Pregnancy/Lactation)

Precautions: Caution in patients with seizure disorders or in those at risk of seizures (CNS mass or medications which may lower seizure threshold). Both new-onset seizure activity as well as an increased frequency of seizures has been observed.

Brands with this active ingredient

• Carniject
• Lekarnitin
• Loovi
• Tinkar

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.