Lefamulin

Other Anti-infective Preps · Pleuromutilin

Indications

Treatment of adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

Dosage

Adults: ORAL: 600 mg orally every 12 hrs for 5 days. IV: 150 mg every 12 hrs by IV infusion over 60 mins for 5-7 days. Children: Not recommended.

Administration

Adm inj by intravenous infusion over 60 mins. Reconstitution: Dilute in a 250 mL soln of 10 mM citrate buffered 0.9% NaCl supplied with Injection. Compatibility: NS. Stability: Before dilution, refrigerate vials at 2-8° C, do not freeze. Store diluent bags at 20-25°C, excursions permitted to 15-30°C. After dilution, inj can be stored for up to 24 hrs at room temp and up to 48 hrs when refrigerated at 2-8°C.

Adverse Effects

Inj: Adm site reactions, hepatic enzyme elevation, nausea, hypokalaemia, insomnia, headache. Tab: Diarrhoea, nausea, vomiting, hepatic enzyme elevation.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Moderate to severe hepatic impairment. Known QT prolongation. Ventricular arrhythmias including torsades de pointes. Patients receiving Class IA or Class III antiarrhythmic agents. Precautions: Mild hepatic impairment. Monitor patients who develop diarrhoea.

Interactions

Midazolam. Class IA (e.g. quinidine, procainamide) or Class III (e.g. amiodarone, sotalol) antiarrhythmic agents. Antipsychotics. Erythromycin. Pimozide. Moxifloxacin. Tricyclic antidepressants.

Advice to Patient

Take at least 1 hr before a meal or 2 hrs after a meal. Swallow tabs whole with water (6-8 ounces). If a dose is missed, the patient should take the dose as soon as possible and anytime up to 8 hrs prior to the next scheduled dose. If <8 hrs remain before the next scheduled dose, do not take the missed dose, and resume dosing at the next scheduled dose. Females of reproductive potential must use effective contraception during treatment and for 2 days after the final dose. Lactating females must avoid lactation and discard milk for the duration of treatment and for 2 days after the final dose.

Pharmacokinetics

Bioavailability: Approx. 25%. Metabolism: Hepatic. Half-life elimination: 8 hrs. Time to peak, plasma: Oral: 0.88-2 hrs. Excretion: Oral: Faeces (88.5%). Urine (5.3%). IV: Faeces (77.3%). Urine (15.5%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.