Lamivudine, Stavudine and Nevirapine

Antiviral, Systemic · Non-nucleoside reverse transcriptase inhibitor/Nucleoside reverse transcriptase inhibitor

Indications

Treatment of HIV-infection.

Dosage

Adults: <60 kg: 1 tab of 30 mg every 12 hr. >60 kg: 1 tab of 40 mg every 12 hr. Children: >14 days, <30 kg: 1 mg of stavudine/kg every 12 hr >30 kg: Same as adult dose. Neonates <2 wk: 500 mcg of stavudine/kg every 12 hr.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Refer individual ingredients for contraindications, precautions, interactions and adverse effects.

Advice to Patient

Take with or without meals. Swallow whole with a glass of water. Do not break, chew or crush tablets. Avoid alcohol during treatment.

Pharmacokinetics

LAMIVUDINE: Absorption: Rapid. Metabolism: Minor, only known metabolite is trans-sulfoxide metabolite. Bioavailability: Absolute. Children: Oral soln: 66% ± 26%; relative bioavailability is 40% lower than with tabs. Adolescents and Adults: Oral soln: 87% ± 13%; Tab 150 mg: 86% ± 16%. Half-life: Intracellular: 10-15 hrs. Elimination: Children 4 mths-14 yrs: 2 ± 0.6 hrs. Adults: 5-7 hrs; increased with renal impairment. Time to peak, plasma: Paediatric patients 0.5-17 yrs: Median: 1.5 hrs. Adolescents 13-17 yrs: 0.5-1 hr. Adults: Fed: 3.2 hrs. Fasted: 0.9 hrs. Excretion: Primarily urine. STAVUDINE: Absorption: Oral: Rapid. Food delays absorption. Metabolism: Intracellular. Bioavailability: 86%. Half-life elimination: 1-1.5 hrs. Time to peak, plasma: 1 hr. Excretion: Urine (40%). NEVIRAPINE: Absorption: Rapid and readily absorbed. Immediate release: >90%. Metabolism: Extensively…

Compiled by Healify Pharmacy from published drug references. How we compile it →

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