Itopride

Antiemetic & Gastroprokinetic · Antiemetic

Indications

Functional dyspepsia. Non-ulcer dyspepsia (chronic gastritis): sensation of bloating, early satiety, upper abdominal pain or discomfort, anorexia, heartburn, nausea and vomiting.

Dosage

Adults: 50 mg three times daily. Children: Not recommended.

Adverse Effects

Diarrhoea, constipation, abdominal pain, increased saliva, nausea, dizziness, headache, tremor.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Gastrointestinal haemorrhage, mechanical obstruction or perforation or in conditions where increase in GI motility will be harmful. Precautions: Itopride enhances the action of acetylcholine and may produce cholinergic effects.

Interactions

Anticholinergic drugs.

Advice to Patient

Take before meals.

Pharmacokinetics

Absorption: Rapid and extensive. Metabolism: Extensive hepatic (FMO1 and FMO3), primarily N-oxidation. Bioavailability: Approx. 60%. Half-life elimination: 5.7 ± 0.3 hrs. Time to peak, plasma: 35 ± 5 mins. Excretion: Renal.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.