Isoprenaline

Cardiac Therapy · Sympathomimetic acting only on beta-adrenergic receptors

Indications

Inj: Hypoperfusion syndrome, cardiac arrest, carotid sinus hypersensitivity, Adams-stokes syndrome, ventricular tachycardia and arrhythmias.

Dosage

Adults: Inj: 0.5-5 mcg/min. Rate 30 mcg/min used in advance stage of shock. See literature.

Administration

Administer infusion through a large vein and monitor patient for signs of extravasation. For IV inf, add 1 mg to 50 mL of compatible IV fluid and administer at 0-60 mL/hr (0-20 mcg/min). Compatibility: NS/D5W, Hartmann's. Stability: Refrigerate. Do not freeze. Protect from light and air. Discard any diluted fluid not used within 24 hrs of preparation. Do not use solution if pinkish to brown in colour or contains precipitate.

Adverse Effects

Flushing, sweating, mild tremor, nervousness, headache, tachycardia.

Risk Factor (Pregnancy/Lactation)

Contraindications: Pre-existing cardiac arrhythmias associated with tachycardia, tachycardia caused by digitalis intoxication. Precautions: Coronary insufficiency, diabetes, hyperthyroidism, patient sensitive to sympathomimetic amines.

Interactions

As for sympathomimetic.

Pharmacokinetics

Onset: Oral: Slow. Duration: Inhalation: 2 hrs. IV: 10-15 mins. Absorption: Inj: Readily absorbed. Metabolism: Hepatic. Lungs. Half-life elimination: IV: Few mins. SC: Up to 2 hrs. Excretion: Urine.

Brands with this active ingredient

• Saventrine

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.