Irbesartan and Hydrochlorothiazide

Angiotensin-II Antagonist · Angiotensin II antagonist/Thiazide diuretic

Indications

Treatment of essential hypertension.

Dosage

Adults: 1 tab daily. Max daily dose: 300 mg irbesartan & 25 mg hydrochlorothiazide. Children: Not recommended.

Adverse Effects

Dizziness, fatigue, headache, flushing, musculoskeletal trauma, nausea/vomiting, abnormal urination, GI upset, increased BUN, creatinine and creatine kinase, photosensitivity (discontinue), acute angle-closure glaucoma (discontinue).

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe renal or hepatic impairment; refractory hyperkalaemia, hypercalcaemia; biliary cirrhosis or cholestasis, primary aldosteronism. Precautions: Patients who are volume and sodium depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or vomiting. Mild to moderate renal or hepatic impairment, bilateral renal artery stenosis, heart failure, diabetes; monitor serum electrolytes, creatinine and uric acid. Aortic or mitral stenosis or obstructive hypertrophic cardiomyopathy, gout, asthma, SLE. Primary aldosteronism. May impair ability to drive or operate machinery.

Interactions

Diuretics & other antihypertensive agents, K supplements and K-sparing diuretics, lithium, hydrochlorothiazide may interact with alcohol, barbiturates, narcotics, antidiabetics, cholestyramine, corticosteroids, ACTH, pressor amines, skeletal muscle relaxants, NSAIDs, digoxin, other drugs affected by serum K+ disturbances, laxatives, amphotericin, benzylpenicillin, hypoglycaemics, colestipol, sympathomimetics, anticholinergics, calcium suppl, vit D, uricosuric agents, amantadine, cytotoxics, carbamazepine.

Advice to Patient

Take with or without meals.

Pharmacokinetics

IRBESARTAN: Onset of action: Peak effect: 1-2 hrs. Max effect: 3-6 hrs postdose; with chronic dosing max effect: Approx. 2 wks. Duration: >24 hrs. Metabolism: Hepatic. Bioavailability: 60%-80%. Half-life elimination: Terminal: 11-15 hrs. Time to peak, serum: 1.5-2 hrs. Excretion: Faeces (80%). Urine (20%). HYDROCHLOROTHIAZIDE: Onset of action: Diuresis: Infants: 2-6 hrs. Adults: Approx. 2 hrs. Peak effect: 4-6 hrs. Duration: Infants: 8 hrs. Adults: 6-12 hrs. Absorption: Well absorbed, absorption is decreased in patients with CHF. Metabolism: Not metabolized. Bioavailability: 65%-75%. Half-life elimination: Approx. 6-15 hrs. Time to peak: Approx. 1-5 hrs. Excretion: Urine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.