Insulin Glargine and Lixisenetide

Insulin · GLP- 1 agonist/Insulin

Indications

As an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus inadequately controlled on basal insulin (<60 units daily) or lixisenatide.

Dosage

Adults: SC: Inject once a day in either thigh, upper arm or abdomen within the hr prior to the first meal of the day. Soliqua 100/33 pen delivers doses from 15-60 units with each injection. Discontinue therapy with lixisenatide or basal insulin prior to initiation of Soliqua 100/33. Patients inadequately controlled on < 30 units of basal insulin or on lixisenatide: Initial dosage is 15 units (15 units glargine/5 mcg lixisenatide). Patients inadequately controlled on 30-60 units of basal insulin: Initial dosage is 30 units (30 units insulin glargine/10 mcg lixisenatide). Max: 60 units daily (60 units of insulin glargine and 20 mcg of lixisenatide). Use alternative antidiabetic products if patients require a SOLIQUA 100/33 daily dosage <15 units or >60 units. Children: Not recommended.

Adverse Effects

Nausea, nasopharyngitis, diarrhea, upper RTI, headache, hypoglycaemia.

Risk Factor (Pregnancy/Lactation)

Contraindications: Pancreatitis. Type 1 DM. Diabetic ketoacidosis. Gastroparesis. During episodes of hypoglycaemia. End-stage renal disease. Precautions: Hepatic and Renal impairment. Hypokalaemia. Pregnancy. Lactation. Elderly.

Interactions

Beta-blockers, clonidine, guanethidine, reserpine, oral contraceptives, sulfonamide antibiotics, acetaminophen, ACE inhibitors, angiotensin II receptor blockers, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somostatin analogues (e.g. octreotide), atypical antipsychotics (e.g. olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents (e.g. albuterol, epinephrine, terbutaline), thyroid hormones, lithium salts, pentamidine.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.