Insulin Degludec and Liraglutide

Insulin · GLP- 1 agonist/Insulin

Indications

Insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise in addition to other oral medicinal products.

Dosage

Adults: Once daily via SC route. Can be administered at any time of the day, preferably at the same time of the day. Administered as dose steps. One dose step contains 1 unit of insulin degludec and 0.036 mg of liraglutide. Max daily dose is 50 dose steps. Add-on to oral glucose-lowering medicinal products: The recommended initial dose is 10 dose steps. When added to sulfonylurea therapy, a reduction in the dose of sulfonylurea should be considered. Transfer from GLP-1 receptor agonist: Therapy with GLP-1 rec agonists should be discontinued prior to initiation of Xultophy. The recommended initial dose is 16 dose steps. Close glucose monitoring is required during the transfer and in the following weeks. Transfer from basal insulin: Therapy with basal insulin should be discontinued prior to initiation of Xultophy. The recommended initial dose is 16 dose steps. Close glucose monitoring…

Adverse Effects

Hypoglycaemia, nausea, diarrhoea, vomiting, constipation, dyspepsia, gastritis, abdominal pain, GERD, abdominal distension, inj-site reaction.

Risk Factor (Pregnancy/Lactation)

Contraindications: End-stage renal disease. Type 1 diabetes mellitus. Diabetic ketoacidosis. Acute pancreatitis. Precautions: Hepatic and renal impairment. Existing thyroid disease.

Interactions

Pioglitazone (discontinue). MAOIs, beta-blockers, ACE inhibitors, salicylates, anabolic steroids, sulfonamides. Oral contraceptives, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormones, danazol. Octreotide. Lanreotide.

Pharmacokinetics

INSULIN DEGLUDEC: Metabolism: Similar to that of human insulin; all metabolites formed are inactive. Half-life elimination: Approx. 25 hrs. LIRAGLUTIDE: Metabolism: Metabolized in a similar manner to large proteins without a specific organ having been identified as major route of metabolism. Half-life elimination: Approx. 13 hrs.

Compiled by Healify Pharmacy from published drug references. How we compile it →

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