Ibuprofen and Codeine

Anti-rheumatic, Systemic · Opioid analgesic/Propionic acid

Indications

Mild to moderate pain.

Dosage

Adults: 1-2 tab 3-4 times daily. Children: Not recommended.

Adverse Effects

Gl upset or bleeding, rash, rarely thrombocytopenia, rarely aseptic meningitis.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Not rated. Lactation: Caution advised or effect undetermined. Contraindications: Active peptic ulcer, aspirin/anti-inflammatory induced allergy. Precautions: Renal, cardiac or hepatic impairment, monitor on long term therapy. GI disease, asthma, elderly.

Interactions

Anticoagulants, thiazide diuretics, quinolones.

Pharmacokinetics

IBUPROFEN: Onset of action: Oral: Analgesic: Within 30 to 60 minutes. Antipyretic: Single oral dose 8 mg/kg: Infants = 1 year: 69 ± 22 minutes; Children =6 years: Single oral dose 8 mg/kg: 109 ± 64 minutes; Adults: <1 hour. Maximum effect: Antipyretic: 2 to 4 hours. Duration: Oral: Antipyretic: 6 to 8 hours. Absorption: Oral: Rapid (85%). Bioavailability: 80%. Metabolism: Hepatic. Half-life elimination: IV: Ibuprofen: Pediatric patients: 6 months to <2 years: 1.8 hours; 2 to 16 years: Approx. 1.5 hours. Adults: 2.22 to 2.44 hours. Ibuprofen lysine: Premature neonates, GA <32 weeks: Reported data highly variable. R-enantiomer: 10 hours; S-enantiomer: 25.5hours. Age-based observations: PNA <1 day: 30.5 ± 4.2 hours. PNA 3 days: 43.1 ± 26.1 hours. PNA 5 days: 26.8 ± 23.6 hours. Oral: Children 3 months to 10 years: Oral suspension: 1.6 ± 0.7 hours. Adults: Approx. 2 hours; End-stage renal…

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.