Hydroxyprogesterone Caproate and Estradiol Valerate

Oestrogen, their Combinations & related Preps · Depot progestogen/Oestrogen

Indications

Prophylaxis of abortion. Threatened abortion.

Dosage

Adults: IM: Prophylaxis of abortion: Three days after the rise in basal body temperature on about the 18th day of the cycle, 1 mL IM. Where failure of the menstrual bleeding and continued elevation of the basal body temperature indicate an early pregnancy, an IM injection of 1 mL is given immediately. The hormone dose is doubled one wk later, i.e. from the beginning of the sixth wk of pregnancy. 2 mL is administered every wk during the first mth of pregnancy, in isolated cases even longer. Therapy is also of advantage when a patient with a predisposition to habitual abortion does not come for treatment until after the start of the fresh pregnancy, 2 mL is injected immediately, followed by 2 mL every wk during the first mth of pregnancy, in isolated cases even longer. Threatened abortion: To institute treatment, 2 mL twice wkly until the bleeding stops. Bed rest is urgently advised…

Adverse Effects

Nausea, vomiting, weight gain, breast tenderness & enlargement, withdrawal bleeding, sodium retention with oedema, liver function disorders, jaundice, rashes, chloasma, headache. Endometrial carcinoma in post-menopausal women.

Risk Factor (Pregnancy/Lactation)

Contraindications: A history of herpes of pregnancy, thromboembolic processes. Precautions: Hypertension, myocardial or renal disease, asthma, varicose veins, epilepsy, chloasma, uterine fibromyomata. Examine BP, pelvic organs & breasts before & regularly during treatment.

Interactions

Diuretics, antihypertensives, liver enzyme inducing drugs.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.