Hydrocortisone and Miconazole, Topical

Corticosteroid Combinations, Topical · Corticosteroid/Imidazole antifungal

Indications

Fungal and gram-positive bacterial infections accompanied inflammation.

Dosage

Adults & Children: Apply once or twice daily.

Adverse Effects

Cushingoid changes, adrenal suppression, local skin reactions, acne, atrophy, striae, telangiectasia, mild pigmentation, hypertrichosis, pruritus, folliculitis. Hypersensitivity reactions incl contact dermatitis (discontinue).

Risk Factor (Pregnancy/Lactation)

Contraindications: Untreated bacterial, fungal or viral infections or parasitic infestations, use on burns, acne or rosacea, perioral dermatitis, widespread plaque psoriasis, perianal or genital pruritus, pruritus without inflammation. Precautions: Do not use potent steroids to treat diaper dermatoses in infants. Avoid extensive or prolonged use (limit to max 7 days in children). If using potent steroids in children or on face, limit to 5 days and avoid occlusion. Avoid mucous membranes and eye area. Broken, inflamed or occluded skin, psoriasis, dermatitis around chronic leg ulcers. Risk of visual disturbances. Elderly.

Advice to Patient

Wash and dry the skin before applying. Apply a thin film to cover affected areas and rub gently. Wash hands thoroughly after applying, unless hands are the area being treated. Contact prescriber if there is no improvement after 7 days. Do not use for more than prescribed period of time. Complete full course of treatment.

Pharmacokinetics

HYDROCORTISONE: Absorption: Absorption is increased in areas that have skin damage, inflammation, or occlusion, or where the stratum corneum is thin such as the eyelids, genitalia, and face. Metabolism: Metabolized in skin. The small amount absorbed into systemic circulation is metabolized hepatically to inactive compounds. Bioavailability: Cream: 4%-19%. Excretion: Urine. MICONAZOLE: Absorption: Little absorption through skin or mucous membranes when applied topically. Metabolism: Hepatic. Half-life elimination: Triphasic; 24 hrs. Excretion: Urine. Faeces.

Brands with this active ingredient

• Albicost
• Caracort
• Daktacort
• Danaderm
• Dermistat HC
• Dermistat HC
• Dipcort
• MiCool-H
• Micosone
• Mycon-H
• Myconit-H
• Remistate HC
• Tecrid-H Topical
• Tineacort
• Zole-F

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.