Hydrocortisone and Fusidic Acid, Topical

Corticosteroid Combinations, Topical · Antibacterial/Corticosteroid

Indications

Inflammatory dermatoses where bacterial infection is present or suspected.

Dosage

Adults & Children: Apply two to three times daily or less frequently if dressing is used.

Adverse Effects

Cushingoid changes, adrenal suppression, local skin reactions, acne, atrophy, striae, telangiectasia, mild pigmentation, hypertrichosis, pruritus, folliculitis. Hypersensitivity reactions incl contact dermatitis (discontinue).

Risk Factor (Pregnancy/Lactation)

Contraindications: Untreated bacterial, fungal or viral infections or parasitic infestations, use on burns, acne or rosacea, perioral dermatitis, widespread plaque psoriasis, perianal or genital pruritus, pruritus without inflammation. Precautions: Do not use potent steroids to treat diaper dermatoses in infants. Avoid extensive or prolonged use (limit to max 7 days in children). If using potent steroids in children or on face, limit to 5 days and avoid occlusion. Avoid mucous membranes and eye area. Broken, inflamed or occluded skin, psoriasis, dermatitis around chronic leg ulcers. Risk of visual disturbances. Elderly.

Advice to Patient

Wash and dry the skin before applying. Apply a thin film to cover affected areas and rub gently. Wash hands thoroughly after applying, unless hands are the area being treated. Contact prescriber if there is no improvement or worsening of condition after 14 days. Do not use for more than prescribed period of time. Do not cover the treated area unless recommended by prescriber. Avoid medication contact with eyes. Do not discontinue medication without consulting prescriber.

Pharmacokinetics

HYDROCORTISONE: Absorption: Absorption is increased in areas that have skin damage, inflammation, or occlusion, or where the stratum corneum is thin such as the eyelids, genitalia, and face. Metabolism: Metabolized in skin. The small amount absorbed into systemic circulation is metabolized hepatically to inactive compounds. Bioavailability: Cream: 4%-19%. Excretion: Urine. FUSIDIC ACID: Absorption: Extent of absorption into skin depends upon factors such as duration of exposure to fusidic acid and the condition of the skin.

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.