Hydrocortisone and Clotrimazole, Topical

Corticosteroid Combinations, Topical · Corticosteroid/Imidazole antifungal

Indications

Corticosteroid responsive dermatoses.

Dosage

Adults & Children: Apply two to three times daily or less frequently if dressing is used.

Adverse Effects

Cushingoid changes, adrenal suppression, local skin reactions, acne, atrophy, striae, telangiectasia, mild pigmentation, hypertrichosis, pruritus, folliculitis. Hypersensitivity reactions incl contact dermatitis (discontinue).

Risk Factor (Pregnancy/Lactation)

Contraindications: Untreated bacterial, fungal or viral infections or parasitic infestations, use on burns, acne or rosacea, perioral dermatitis, widespread plaque psoriasis, perianal or genital pruritus, pruritus without inflammation. Precautions: Do not use potent steroids to treat diaper dermatoses in infants. Avoid extensive or prolonged use (limit to max 7 days in children). If using potent steroids in children or on face, limit to 5 days and avoid occlusion. Avoid mucous membranes and eye area. Broken, inflamed or occluded skin, psoriasis, dermatitis around chronic leg ulcers. Risk of visual disturbances. Elderly.

Advice to Patient

Wash and dry the skin before applying. Apply a thin film to cover affected areas and rub gently. Wash hands thoroughly after applying, unless hands are the area being treated. Do not use for more than prescribed period of time.

Pharmacokinetics

HYDROCORTISONE: Absorption: Absorption is increased in areas that have skin damage, inflammation, or occlusion, or where the stratum corneum is thin such as the eyelids, genitalia, and face. Metabolism: Metabolized in skin. The small amount absorbed into systemic circulation is metabolized hepatically to inactive compounds. Bioavailability: Cream: 4%-19%. Excretion: Urine. CLOTRIMAZOLE: Absorption: Negligible systemic absorption. Metabolism: Hepatic. Excretion: Urine. Faeces.

Brands with this active ingredient

• Aquazole
• Arsocortison-C
• Canix-H
• Clometa-H
• Clozole-H
• Clozox H, Topical
• Conate-HC
• Creamazole-H
• Curezole
• Dermosporin HC
• Femecare-H
• Gytrim-HC
• Hyclozole
• Hydrotrim
• Hydrozole

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.