Hydrocortisone and Chloramphenicol, Eye

Corticosteroid Combinations, Eye · Chloramphenicol/Corticosteroid

Indications

Ocular infections.

Dosage

Adults & Children: Apply once daily to once hourly depending on severity.

Adverse Effects

Rise in intra-ocular pressure, corneal thinning, cataract. Aplastic anaemia (rare).

Risk Factor (Pregnancy/Lactation)

Contraindications: Viral, fungal, tuberculous or purulent infections. Glaucoma. Precautions: Prolonged use in pregnancy or infants.

Advice to Patient

Wash hands properly before use. To instill medication into eyes, tilt head back, look upward, instill drops or apply thin layer of ointment inside lower eyelid. Close eye and roll eyeball in all directions. Do not blink for 30 seconds. Apply gentle pressure to inner corner of eye. Contact prescriber if there is eye pain, changes in vision, no improvement or worsening of condition. Avoid touching tip of applicator with eye. Do not share medication with anyone else.

Pharmacokinetics

HYDROCORTISONE: Absorption: Well-absorbed into the eye. Systemic absorption is negligible. CHLORAMPHENICOL: Absorption: Well absorbed. Metabolism: Hepatic. Half-life elimination: Adults (normal hepatic and renal function): 1.5-3.5 hrs. Impaired renal function: 3-4 hrs. Severely impaired hepatic function: 4.6-11.6 hrs. Children (1 mth-16 yrs): 3-6.5 hrs. Infants 1-2 days old: 24 hrs or longer and is highly variable, esp in low birth-wt infants.

Brands with this active ingredient

• Neo-Phenicol HC

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.