Ganirelix

Drugs affecting Gonadotrophin · Anti-gonadotrophic agent

Indications

Prevention of premature luteinising hormone surges in women undergoing controlled ovarian hyperstimulation for assisted reproduction techniques.

Dosage

Adults: 0.25 mg once daily by SC inj in upper leg starting on day 6 of FSH administration. Continue upto and including day of ovulation induction. Children: Not applicable.

Administration

For SC administration only. The most convenient sites for SC injection are in the abdomen around the naval or upper thigh. Stability: Store at 25°C (77°F). Protect from light.

Adverse Effects

Injection site reactions, headache, nausea.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Moderate or severe renal or hepatic impairment, severe allergic conditions. Precautions: Active allergic conditions. Latex allergy. Risk of ovarian hyperstimulation.

Advice to Patient

Administer as directed by prescriber. Contact prescriber if there is vaginal bleeding, sudden pain in stomach or pain, itching or signs of infection at injection site. Inform prescriber if you have latex allergy because packaging may contain natural rubber latex. Take mild analgesic if headache occurs.

Pharmacokinetics

Absorption: SC: Rapidly absorbed following SC inj. Metabolism: Converted to 1-4-peptide metabolite and a 1-6-peptide metabolite, but the route of metabolism is uncertain. Bioavailability: Absolute: 91%. Half-life elimination: 16 hrs. Time to peak, serum: Within 1 hr. Excretion: Urine (18%). Faeces (75%).

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.